Medicinal Chemistry topics

Our Team has a consolidated experience in the design, synthesis and SAR study of covalent and non-covalent enzymatic inhibitors, exploiting target-based approaches. Our research activities are currently focused on the development of reversible and covalent inhibitors targeting protein kinases as novel anticancer agents, with particular focus on pancreatic cancer. 

In addition, we are investigating nature-inspired covalent inhibitors targeting parasitic enzymes for the development of novel agents to fight malaria and other protozoan infectious diseases.